For the podcast’s one-year anniversary, we zoom out from single studies to examine a comprehensive masterpiece: the doctoral thesis of Jolien K.E. Veraart, representing nine years of research (2016–2026) at the University of Groningen. This document moves beyond the initial hype of “does it work?” to the mature, difficult questions of long-term maintenance and safety.

We unpack the critical concept of auto-induction—the discovery that the liver eventually “learns” to metabolize ketamine so efficiently that stable doses stop working, creating a bioavailability trap that looks like relapse but is actually just enzymatic efficiency. The episode also tackles the “nightmare” of oral dosing, where absorption is so variable that it makes consistent treatment a roll of the dice.

Finally, we d ...