In 2002 Women's Health Initiative (WHI) study showed that traditional synthetic hormone replacement therapy increased risk of cancer and heart disease.,

“After that, clinicians decided they no longer needed to worry about being educated about menopause because there was really nothing to do for menopause if we weren't going to use hormone therapy.” — Stephanie Faubion MD, director of the Mayo Clinic Center for Women's Health and medical director for the Menopause Society.