"Given the methodological heterogeneity and distinct patient populations enrolled in the DISTAL and ESCAPE-MeVO trials, caution is warranted when attempting to synthesize or directly compare their findings. The disparate designs and inclusion criteria limit the cumulative interpretability of the results, necessitating independent evaluation of each study's conclusions. Furthermore, the following nuances necessitate careful consideration when interpreting each study's findings, as they may significantly influence the reader's understanding of the efficacy and safety of endovascular treatment for medium and distal vessel occlusions."🔴 Vessel Definition & Patient Population:DISTAL (Broader): Diluted EVT benefit due to inclusion of potentially less severe distal occlusions and exclusion of known EVT-responsive dominant M2s. Impact: Underestimati ...