Multiomics Playbook - 4th Edition

Multiomics Playbook - 4th Edition

di Front Line Genomics

Medicina Scienza

Chapter 6 - Applications In The Digital Era

THE EVER-INCREASING ABUNDANCE OF MULTIMODAL DATA PROVIDES EXTENSIVE OPPORTUNITIES FOR THE DISCOVERY OF NOVEL INSIGHTS THROUGH MINING AND REANALYSIS. FROM ATLASES TO SIMULATIONS, BIOLOGICAL LANGUAGE MODELS AND SYNTHETIC DATASETS, WE EXPLORE HOW MULTIOMICS DATA IS INFORMING THE DIGITAL ERA, AND HOW WE ALL HAVE A ROLE TO PLAY IN GENERATING DATA THAT WILL BE USEFUL BEYOND ITS INITIAL PURPOSE.

Chapter 5 - Applications For Precision Medicine

MULTIOMICS IS REVOLUTIONISING THE FIELD OF PRECISION MEDICINE. FROM BOLSTERING DRUG DISCOVERY AND DEVELOPMENT, TO IMPROVING PATIENT DIAGNOSIS AND STRATIFICATION, MULTIMODAL TESTING IS PAVING THE WAY FOR PERSONALISED MEDICINE AND HOLISTIC HEALTHCARE. THIS CHAPTER INVESTIGATES SEVERAL CASE STUDIES THAT EXEMPLIFY THE USE OF MULTIOMICS IN PRECISION MEDICINE, SUCH AS THE DEVELOPMENT OF PERSONALISED VACCINES AND THE USE OF ELECTRONIC HEALTH RECORDS IN MULTIMODAL PLATFORMS.

Chapter 4 - Multimodal Integration and Analysis

ONE OF THE KEY CHALLENGES FACING MULTIOMICS RESEARCH IS THE INTEGRATION OF DATA. A WEALTH OF COMMERCIAL AND OPEN- SOURCE SOLUTIONS EXISTS, WITH MANY OFFERING MACHINE LEARNING CAPABILITIES TO DRAW INSIGHTS FROM SEEMINGLY DISPARATE DATA. HERE, YOU WILL DISCOVER NOVEL PUBLICATIONS DISCUSSING THE KEY CHALLENGES FACING DATA INTEGRATION, ALONGSIDE INTERVIEWS AND INSIGHTS FROM THE AUTHORS GIVING CLARITY AND EXPERT ADVICE. TOPICS INCLUDE DATA HETEROGENEITY, THE CURSE OF DIMENSIONALITY AND SOLUTIONS FOR THOSE WITHOUT BIOINFORMATICS EXPERTISE.

Chapter 3 - Beyond the Central Dogma

THE APPLICATIONS OF MULTIOMICS RESEARCH EXTEND FAR BEYOND THE CENTRAL DOGMA. MULTIMODAL TECHNIQUES ARE BEING USED TO MAP THE SECRETOME, INTERACTOME AND HOLOGENOME, AMONGST OTHERS. THIS CHAPTER EXPLORES THE POSSIBILITIES OF MULTIOMICS RESEARCH AT A SYSTEMS BIOLOGY LEVEL, FROM HOW ENDOPHENOTYPE RESEARCH IS BRIDGING SCALES BETWEEN MOLECULES AND PHENOTYPES, TO HOW MULTIMODAL ANALYSIS OF THE EXPOSOME CAN SHED LIGHT ON THE BIOLOGICAL IMPACT OF AN INDIVIDUAL’S ENVIRONMENT.

Chapter 2 - Spatial Multiomics

MULTIOMICS ANALYSIS HAS SHOWN GREAT PROMISE FOR INVESTIGATING TISSUE, ALLOWING THE INTERROGATION OF MULTIPLE MODALITIES THAT ARE COMPLEMENTED BY MORPHOLOGICAL AND SPATIAL CONTEXT. THIS CHAPTER DISCUSSES THE TYPES OF SINGLE OMES THAT CAN BE COMBINED IN SPATIAL STUDIES, CONSIDERING BOTH COMMERCIAL AND OPEN-SOURCE APPLICATIONS. DIGITAL PATHOLOGY IS HIGHLY COMPATIBLE WITH SPATIAL MULTIOMICS; HISTOLOGY IS ROUTINELY PERFORMED, AND WE EXPLORE HOW THIS MORPHOLOGICAL INFORMATION CAN BOLSTER SPATIAL STUDIES AND INSIGHTS.

Chapter 1 - Combining Proteins and Nucleic Acids

BIOLOGICAL PROCESSES ARE GROUNDED IN THE CENTRAL DOGMA, EACH LAYER OFFERING UNIQUE INSIGHTS. BRINGING THESE MODALITIES TOGETHER BUILDS A CLEARER PICTURE OF CELLULAR BIOLOGY, WHILE GENERATING A WEALTH OF DATA FOR FUTURE INVESTIGATION. HERE, WE EXPLORE A SELECTION OF COMMERCIAL AND OPEN-SOURCE PLATFORMS THAT COMBINE PROTEIN AND NUCLEIC ACID DETECTION, DETAILING THEIR BENEFITS AND LIMITATIONS, WHILE PROVIDING RECENT USE CASES. THE CRUCIAL ROLE OF THE WET LABORATORY SCIENTIST IS ALSO DISCUSSED AS WE MOVE INTO THIS DIGITAL ERA.

Introduction

Foreword