Dr. Jessica Pelletier, Dr. Sidwell Kyeyune, and Dr. Kakande Reagan discuss the epidemiology, pathophysiology, clinical presentation, diagnostic workup, management, and prevention of Marburg virus disease.

Take-Home Points:

• Marburg virus disease infection can occur via zoonotic exposure to Egyptian fruit bats or via human-to-human transmission.
• Initial symptoms are non-specific but can progress to hemorrhage, multiorgan failure, and death.
• Diagnosis involves RT-PCR.
• Treatment is mostly supportive, including blood products (for bleeding), IV fluid resuscitation, and symptom control (with avoidance of NSAIDs).
• Remdesivir and monoclonal antibodies may be given under compassionate use.
• PPE involves standard, contact, and droplet precautions, with environmental decontamination via chlorine ...