Linus Pauling, Christian Anfinsen, and Cyrus Levinthal meet in a pub to debate the folding and function of proteins, and how Darwin's thinking provided a solution to an almost impossible problem. However, how do you make a protein with a completely novel function that nature has not yet invented?

[There is an unfortunate historical error here: Anfinsen was an American biochemist, not Swedish. Mea culpa...I was unable to correct the error of his name and nationality in time for the production of the book.]