Neuroscientist Stuart Firestein (Columbia University) joins Breaking Math to make an extravagant claim: uncertainty isn't a weakness in science — it's the defining feature that makes progress possible. In this episode, we break down why the "one right answer" myth is one of the most damaging ideas in science, why real experts are often the most uncertain people in the room, and why authority and expertise pull in opposite directions, covering two fundamentally different kinds of probability, why Darwin never erased a 300-year-old classification system built on an assumption he disproved, why AI is exceptional at prediction but not built for causation, and why pseudoscience always has a confident answer while real science rarely does — plus the philosophical difference between hope and optimism, and why Voltaire had to invent the word "optimism" i ...