Methylation: Beyond MTHFR, The Masterswitch that most execs ignore or don't know enough about.
Methylation is one of the most fundamental biochemical processes in the human body, occurring billions of times per second, in every cell. It governs gene expression, neurotransmitter production, detoxification, and how your body responds to sustained stress among so many other things. Yet many high-performing executives don't fully understand how important it is, and those who have heard of it, often think it begins and ends with MTHFR. In this episode, Lisa Cutforth unpacks what methylation actually is, why it matters for cognitive performance, resilience, and your healthspan and what happens when it quietly breaks down. No hype. Just the science, and your body of evidence and what to do about it. Reference List: 1. Cui H, Xie N, Banerjee S, et al. Methylation across the central dogma in health and diseases: new therapeutic strategies. Signal Transduction and Targeted Therapy. 2023;8:310. https://www.nature.com/articles/s41392-023-01528-y 2. Fitzgerald KN. How Targeting DNA Methylation Affects These 6 Common Conditions. drkarafitzgerald.com, 4 June 2024. https://www.drkarafitzgerald.com/2024/06/04/how-targeting-dna-methylation-affects-these-6-common-conditions/ 3. Menezo Y, Clement P, Clement A, Elder K. Methylation: An Ineluctable Biochemical and Physiological Process Essential to the Transmission of Life. International Journal of Molecular Sciences. 2020;21(23):9311. https://doi.org/10.3390/ijms21239311 4. UNSW Newsroom. ‘How do we know what we don’t know?’: scientists completely define the process of methylation. 1 June 2023. https://www.unsw.edu.au/newsroom/news/2023/06/-how-do-we-know-what-we-don-t-know----scientists-completely-defi 5. Kiselev IS, Kulakova OG, Boyko AN, Favorova OO. DNA Methylation As an Epigenetic Mechanism in the Development of Multiple Sclerosis. Acta Naturae. 2021;13(2):45–57. https://doi.org/10.32607/actanaturae.11043 6. Fitzgerald KN, Hodges R, Hanes D, et al. Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial. Aging. 2021;13(7):9419–9432. 7. Walsh WJ. Nutrient Power: Heal Your Biochemistry and Heal Your Brain. New York: Skyhorse; 2014. (Clinical undermethylation/overmethylation typology, applied here as one interpretive lens.)