Source: Kreider, R.B.; Stout, J.R. Creatine in Health and Disease. Nutrients 2021, 13, 447.

Main Themes:

• Review article explores creatine's therapeutic potential beyond its ergogenic benefits.
• Authors discuss creatine's metabolic effects, energy availability, and implications for diseases involving the creatine kinase/phosphocreatine system.

Key Ideas and Facts:

Metabolic Role:

• "Creatine and phosphagens play a critical role in providing energy through the creatine kinase (CK) and PCr system. The free energy yielded from the enzymatic degradation of adenosine triphosphate (ATP) [...] serves as a primary fuel to replenish ATP for cellular metabolism."

Therapeutic Potential: ...