IA
CC Pharm | Piperacillin/ Tazo [Zosyn]
IA
STAT Stitch Deep Dive Podcast Beyond The Bedside di Regular Guy
Note sull'episodio
Zosyn (Piperacillin/Tazobactam) 80/20 Clinical Summary
Core Classification & Mechanism
- Drug Class: Zosyn is an injectable combination of piperacillin (extended-spectrum penicillin) and tazobactam (beta-lactamase inhibitor).
- Bactericidal Action: Piperacillin binds to penicillin-binding proteins (PBPs), inhibiting cell wall synthesis and causing autolysin-mediated lysis.
- Beta-Lactamase Protection: Tazobactam is an irreversible inhibitor of beta-lactamases (Sykes types II–V, staphylococcal penicillinase, and ESBLs), shielding piperacillin.
- Pharmacodynamics: Exhibits time-dependent (concentration-independent) killing, relying on time free ...
Parole chiave
Nursing Pharmacology ReviewER / trauma nursingCritical care nursingNursing exam reviewNursing educationNursing lecturesNursing fundamentalsNursing clinicalsPharmacology dosing