Vasopressin (Vasostrict) Clinical Reference

1. Action: Exogenous ADH analog. Promotes renal water reabsorption via cAMP. Directly contracts vascular smooth muscle non-adrenergically. 2. Use: Raising BP in vasodilatory shock refractory to fluids/catecholamines; post-op abdominal distention. 3. Complications: Cardiac arrest, bradycardia, MI, AFib, water intoxication, severe hyponatremia, necrosis. 4. Admin: IV infusion must go through central vein. If peripheral, use >=20G catheter & check frequently. Premixed (0.4/0.6 units/mL) needs no dilution. Dilute 20 units/mL to 0.1 or 1 unit/mL in NS/D5W. Discard after 18h room temp, 24h refrigerated. IM/SC duration is 2-8h; IO used in CPR. 5. Contraindications: No renal/hepatic adjustments nee ...