In this episode, we're privileged to host Dr. Finger, a leading figure in the field of pancreatic islet transplantation. We explore the intricacies of this potentially life-altering treatment for diabetes, which, while promising, faces significant hurdles related to the supply chain and quality control of donor islets.

Dr. Finger takes us through the transformative potential of cryopreservation to solve these challenges. The key, he explains, lies in the meticulous optimization of cryoprotectant agent composition, loading and unloading conditions, and methods for vitrification and rewarming. This strategy can successfully preserve islets from a variety of sources, including mice, pigs, humans, and even human stem cell-derived beta cells.

Our discussion reveals that these post-cryopreservation islets maintain high viability, not only i ...