Breaking Barriers in Embryo Research: Ex utero mouse embryogenesis with Dr. Alejandro A-Castrejon

Science Society di Catarina Cunha

Note sull'episodio

Step into the cutting-edge world of embryogenesis with Dr. Alejandro A-Castrejon from the Weizmann Institute of Science. While our grasp on the early stages of mammalian development has steadily grown over the years, the phase after implantation into the maternal uterus has remained somewhat elusive. But all that is about to change.

Dr. Alejandro A-Castrejon unveils groundbreaking platforms for the ex utero culture of post-implantation mouse embryos. This transformative approach allows researchers to mimic in utero development precisely from before gastrulation (at embryonic day, or E, 5.5) up until advanced organogenesis stages (E11) – all outside the womb. With a strategic mix of static and rotating bottle culture platforms, these embryos are nurtured in conditions that beautifully recreate their natural growth environment.

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Parole chiave
single cell rna sequencingartificial embryogenesisweizmann institute of scienceembryonic perturbationsex utero culturepost implantation mouse embryosorganogenesisrotating bottle culturehistological analysisembryogenesis research