Does sertraline cause weight gain — and is alcohol safe while taking it?

Sertraline is a selective serotonin reuptake inhibitor (SSRI) used to treat depression and anxiety. Weight changes and alcohol interactions are common concerns. In this episode, we explain the evidence and how treatment safety is assessed in Europe.

In this episode, we cover:

• What sertraline is and how it works (SSRI mechanism)

• Short-term vs long-term weight changes

• Appetite, metabolism, and behavioural factors

• Differences between weight gain and recovery-related appetite changes

• Alcohol interaction risks: sedation, impaired judgement, mood effects

• Impact on sleep and sexual function

• When dose adjustment may be considered

• When switching antidepressants may be appropriate

•  ...