Salmon sperm on your face sounds absurd until you learn it's one of the most clinically validated bioregenerative treatments to emerge from Korean dermatology. This episode breaks down PDRN—polydeoxyribonucleotide—the purified nucleotide compound that signals your skin to rebuild collagen as if healing a wound, without causing actual damage. If you've hit the point where hydration alone doesn't restore firmness and you're curious whether this treatment lives up to the science, Marcus Vance explains exactly what's happening at the cellular level and what concentrations actually deliver results.

• PDRN is extracted from salmon sperm and processed into low-molecular-weight DNA fragments (50–1,500 base pairs) small enough to penetrate the dermis and activate adenosine A2A receptors, the same receptors that regulate inflammation and collag ...