Dr. Jessica Pelletier and Dr. Mulungi Jonathan discuss the epidemiology, pathophysiology, clinical presentation, diagnostic workup, management, and prevention of cryptococcosis.

Take-Home Points:

• Cryptococcus is deadly and demands early recognition.
• Most global burden is in Sub‑Saharan Africa.
• Crypto isn’t just an HIV disease.
• CNS and lungs are the most commonly affected organs.
• CrAg LFA is the best diagnostic tool in resource‑limited settings.
• Elevated intracranial pressure is the major killer.
  • Positive pulmonary crypto requires a lumbar puncture - even without neuro symptoms.
• After managing the ABCDs, treatment = antifungals + ICP control + supportive care.

You can view the full show notes and references here: