Episode 10 Dr Mauro Perretti

“Immunoresolvents & Resolution Pharmacology: From Annexin A1 to SPMs with Dr. Mauro Perretti”

In this episode we welcome Professor Mauro Perretti, a leading pioneer in immunopharmacology and the biology of inflammation resolution. We discuss his career path from Florence to the William Harvey Research Institute, his foundational work on Annexin A1, his collaboration with Charles Serhan, the concept of immunoresolvents, Specialized Pro-resolving Mediators (SPMs), neutrophil microvesicles, and the emerging field of resolution pharmacology. Key themes include why inflammation is not inherently “bad,” what mainstream medicine still overlooks, the therapeutic potential of SPMs and Annexin A1 in arthritis and chronic inflammation, mentorship of prominent res ...