Welcome to Season 2, Episode 1 of The Clinical Chronicle.

This episode delivers major practice-changing updates in medicine for 2026, including the new AHA and ASA acute ischemic stroke guideline, evolving evidence on sodium correction in severe hyponatremia, and why current lung cancer screening criteria may be missing more than 60 percent of patients at diagnosis.

We break down expanded eligibility for endovascular thrombectomy in larger core strokes, the shift toward dual antiplatelet therapy over thrombolysis for minor nondisabling stroke, and updated blood pressure management recommendations in acute ischemic stroke. These changes are highly relevant for hospitalists, emergency physicians, neurologists, and internal medicine residents preparing for ABIM and ITE exams.

We also examine new data challenging long-standing slow  ...