In this pivotal episode of The Bone Health Basement Tapes, host Peter Bianco is joined by Dr. Mary Bouxsein—Professor of Orthopedic Surgery at Harvard Medical School and a central leader behind the SABRE initiative—alongside Dr. Shannon Carpenter, founder of The Bone Health Clinic.

At the center of the conversation is SABRE (Study to Advance Bone Mineral Density as a Regulatory Endpoint), a landmark effort that has reshaped the future of osteoporosis drug development. Drawing on data from over 50 clinical trials and more than 160,000 patients, SABRE demonstrated that changes in bone mineral density (BMD) can reliably predict fracture risk reduction—paving the way for smaller, faster, and more efficient clinical trials.

But this episode goes far beyond regulatory science.

Together, the group explores why this moment may  ...