“If this works, we can make the entire global economy a trillion dollars bigger… That’s a massive opportunity for humanity.” — Brian O’Kelley

Brian O’Kelley has made over $2B in selling his businesses — Inventor of the ad exchange, former CEO of AppNexus (acquired for $1.6B), Right Media (acquired for $600M) and now CEO of Scope3 — has shaped the economic and technical foundations of the open internet. In this episode, Samraj speaks with Brian about AI, agentic ecosystems, sustainability, and why the future of advertising will reward experimentation over determinism.

A sharp, fast-moving conversation on trillion-dollar market shifts, the collapse of legacy ad models, new protocols, and what AI-native companies understand that incumbents don’t.

EPISODE HIGHLIGHTS

0:00 ➤ Intro / Guest Welcome

3:10 ➤ Early Amex w ...