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Methergine (methylergonovine) is an oral and parenteral semisynthetic ergot alkaloid derivative classified as a labor inducer. It is primarily indicated for the management and prevention of postpartum uterine atony, subinvolution of the uterus, and postpartum hemorrhage following the delivery of the placenta or the anterior shoulder.

Mechanism of Action The drug acts directly on uterine smooth muscle to increase the tone, rate, amplitude, strength, duration, and frequency of rhythmic contractions. This rapid and sustained tetanic uterotonic effect reduces blood loss and shortens the third stage of labor. Pharmacologically, me ...