This is everything Aminoglycosides.

PHARMACOLOGY STUDY GUIDE: AMINOGLYCOSIDES

Drugs: Amikacin, Gentamicin, Tobramycin, Neomycin, Streptomycin Class: Anti-infective; bactericidal via 30S ribosomal inhibition.

Key Mechanism & Uses

MOA: Inhibits bacterial protein synthesis (30S ribosome) → kills bacteria. Use: Serious gram-negative infections (Pseudomonas, E. coli, Klebsiella, Proteus, Serratia). Often combined with penicillins or other agents for staph, endocarditis, or TB. Special Uses:

• Neomycin: Pre-op bowel prep, hepatic encephalopathy.
• Tobramycin (Inhaled): CF with Pseudomonas. PK: Well absorbed IM, full bio ...