The FDA's role in public health is questioned regarding Oxy, a drug linked to addiction and deaths. The US opioid crisis, fueled by fentanyl, has driven overdose deaths, as reported by the CDC. The DEA combats illicit drugs, but the problem stems from brain opioid receptors causing addiction and overdose. The US military and veterans are also affected. Narcan saves lives but is a temporary fix. Addressing the crisis requires understanding addiction neuroscience, opioid receptors, and a joint strategy from the FDA, CDC, and DEA. A multifaceted approach including education, law enforcement, and addiction science is needed to prioritize public health.