Serious rash risk tracks the speed of dose escalation, not the final dose — slow titration moves it from roughly 1 in 100 to about 1 in 2,500. Two hosts walk the six-week bipolar schedule step by step (25 → 50 → 100 → 200 mg, two weeks at each of the first two steps), the interactions that change every number (valproate halves them, enzyme inducers double them, estrogen-containing contraceptives complicate them), and how to tell a benign rash from the one that means stop now. Protocol and dosing tables: https://psychnpfellowship.com/lamotrigine-rash-titration-protocol-pmhnp-2026/