Notas del episodio
Epigenomics examines heritable or persistent changes in gene regulation that do not require changes in the underlying DNA sequence. Major epigenetic features include DNA methylation, histone modifications, chromatin accessibility, nucleosome positioning, and three-dimensional chromatin interactions. Because each feature requires a different experimental assay, the computational analysis also differs.
Palabras clave
ChIP-seq, bisulfite-seq, Methylation, Histone modification