Dr. Mathuram Santosham scored J3 on his qualifying exam—the second-worst grade possible. His headmaster said medical school was impossible. But one teacher fought for him, and that changed everything. From watching children die of dehydration in 1960s India to revolutionizing treatment on Apache reservations to eliminating meningitis globally, Dr. Santosham shares why dreaming big, embracing failure, and lifting others up are the keys to an impactful career in medicine.