The provided text outlines a comprehensive expert recommendation and roadmap for the future of high-grade serous carcinoma (HGSC) research and treatment. Drawing from the 15th Helene Harris Memorial Trust International Forum, the document synthesizes a decade of progress while identifying critical gaps in early detection and acquired resistance. It highlights the shift toward recognizing the Fallopian tube as the primary site of origin, which has revolutionized prevention strategies like opportunistic salpingectomy. The authors emphasize the complexity of the tumour microenvironment and the need for personalized immunotherapy to overcome the limitations of current treatments. Ultimately, the source advocates for international collaboration and innovative clinical trial designs to address social disparities and improve long-term survival rates.