In this episode of The Psychology Undergrad, we put depression’s most famous explanation on trial: the “chemical imbalance.” From the Zoloft blob to the empty-tank serotonin metaphor, we trace how a simple story became mental health folklore—then collide it with the academic record. We weigh Ronald Pies’ claim that psychiatry never endorsed the idea against research digging through journals and textbooks from the SSRI boom years. Then we hit the uncomfortable core: was the myth a “noble lie” meant to reduce stigma, or a breach of informed consent that pushed medication as the default solution? We close with what comes after serotonin— inflammation, BDNF, glutamate—and the harder truth the myth protected us from.

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