The New Orleans Saints suffer another heartbreaking loss, this time to the San Francisco 49ers in Week 2 of the NFL season. James Skrmetta reacts and breaks down the full game, giving you a complete recap and review of how the Saints fell short in a 26-21 defeat.

Mac Jones stepped in for the injured Brock Purdy and delivered his best game in years, throwing for 279 yards and three touchdowns to lead the 49ers past the Saints. Spencer Rattler showed flashes with three touchdown passes of his own, but New Orleans’ rookie coach Kellen Moore still searches for his first win.