Lanoxin (Digoxin) 80/20 Clinical Summary

1. Expected Action & Mechanism

• Positive Inotrope: Inhibits the Na+/K+-ATPase pump1, raising intracellular sodium. This reverses sodium-calcium exchange to increase intracellular calcium, boosting myocardial contractility, force, and velocity12.
• Negative Chrono/Dromotrope: Increases vagal activity, slowing AV nodal conduction and prolonging refractory period to slow ventricular rate3.

2. Therapeutic Use & Selection

• Indicated for heart failure (HF) and controlling ventricular rate in chronic atrial fibrillation (AF)4. Off-label for fetal supraventricular tachyarrhythmias5.
• Benefit: Boos ...