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CC Pharm | Dopamine
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STAT Stitch Deep Dive Podcast Beyond The Bedside por Regular Guy
Notas del episodio
- Dose-Dependent Mechanism: Dopamine is a metabolic precursor to norepinephrine. Clinical effects depend entirely on the infusion rate:
- Low Dose (< 5 mcg/kg/min): Stimulates dopaminergic D1 and D2 receptors in renal, mesenteric, coronary, and cerebral beds, causing vasodilation and increasing blood flow.
- Intermediate Dose (5 to 10 mcg/kg/min): Stimulates dopaminergic and beta-1-receptors, increasing cardiac contractility, chronotropy, and mildly raising systemic vascular resistance.
- High Dose (> 10 mcg/kg/min): Stimulates alpha-receptors, causing potent vasoconstriction. Rates > 20 mcg/kg/min frequently cause arrhythmias or severe vasoconstriction.
- Key Indications: Dopamine provides hemodynamic support in distributive shock (e.g., sep ...
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