In this episode, we welcome Dr. Kannan and his team, pioneers in neuroscience and the developers of Genetically Encoded Fluorescent Voltage Indicators (GEVIs). They share the intricate dynamics of signal processing in the brain, involving various excitatory and inhibitory neuron populations.

Dr. Kannan's team discusses their innovations, including the second-generation GEVIs Ace-mNeon2 and VARNAM2. These have shown significantly improved voltage sensitivities and, along with their respective reverse response-polarity variants, provide an unparalleled suite of tools for multi-population voltage recordings in awake, behaving animals.

The team also talks about their experiments involving these indicators, which allowed low-power recordings from a vast number of individual neurons in running mice. These investigations have unveiled fasc ...