Title: "Exploring Tumour Neo-Innervation and Anti-Tumour Immunity with Dr. Talbot"

Description:

The innervation of solid tumors by pain-initiating sensory neurons or nociceptors and its implications on cancer immunosurveillance is a subject of immense interest. In this episode, we're joined by Dr. Talbot, who discusses how melanoma cells interact with nociceptors, leading to their increased neurite outgrowth, sensitivity to noxious ligands, and neuropeptide release.

Dr. Talbot delves into how Calcitonin Gene-Related Peptide (CGRP), a nociceptor-produced neuropeptide, can directly amplify the exhaustion of cytotoxic CD8+ T cells, limiting their ability to eliminate melanoma. Strategies like the genetic ablation of the TRPV1 lineage, local pharmacological silencing of nociceptors, and antagonism of the CGRP receptor RAMP1 all sho ...