Join us for an enlightening episode featuring Dr. Miller, who shares his research focusing on the impact of mitochondrial DNA variants, particularly mitochondrial SNP rs2853499, on Alzheimer's Disease (AD), neuroimaging, and transcriptomics.

Dr. Miller's team successfully mapped this SNP to a new mitochondrial small open reading frame called SHMOOSE, which has the potential to encode a microprotein. For the first time ever, they have detected two unique SHMOOSE-derived peptide fragments in mitochondria using mass spectrometry, marking an exciting breakthrough in the detection of mitochondrial-encoded microproteins.

We delve into how levels of SHMOOSE in human cerebrospinal fluid (CSF) correlate with age, CSF tau, and brain white matter volume, providing crucial insight into the potential role of this microprotein in the onset and prog ...