In this episode, we explore how groundbreaking scientific advancements are providing solutions to prevent injury to the cardiac conduction system (CCS) during heart surgeries, a critical yet elusive network of cells embedded within the heart. Our guest, Dr. Goodyer, is leading the charge in this domain.

Dr. Goodyer's team has engineered targeted antibody-dye conjugates that specifically bind to the CCS, enabling its visualization in mice in vivo with high sensitivity, specificity, and resolution. This development provides the potential to avoid accidental damage to the CCS during cardiac procedures.

Expanding on this innovation for human use, Dr. Goodyer's team developed a fully human monoclonal Fab that targets the CCS with high specificity. Interestingly, this Fab can also be used to modulate CCS biology when linked to a different c ...