Novel Strategy to Tackle Antibiotic Resistance: Dr. Mavridou's research presents a novel approach to combat antibiotic resistance. By targeting a single non-essential bacterial protein, DsbA, the team was able to inhibit multiple antibiotic resistance (AMR) determinants.

DsbA and its Role: DsbA, a protein unique to bacteria, plays a significant role in the function of various resistance enzymes. By inhibiting this protein, the research team managed to sensitize certain pathogens to existing antibiotics, making those drugs effective once again.

β-lactamase Enzymes and DsbA: A significant focus was placed on β-lactamase enzymes, which confer resistance to a range of antibiotics. By targeting DsbA, these enzymes were incapacitated, especially those that aren't affected by classical β-lactamase inhibitors. This is especially relevant as m ...