In this final episode of the series, attention returns to how nuclear responsibilities are talked about, with particular emphasis on the Treaty on the Non-Proliferation of Nuclear Weapons (NPT) and its review cycle. In the episode, Dr Megan Dee and Dr David Chambers (Head of the Arms Control and Disarmament Research Unit, Foreign, Commonwealth and Development Office, United Kingdom) discuss the different framings and approaches that can be used – and avoided – by States when talking nuclear responsibilities in an NPT framework, as well as the merits of using a nuclear responsibilities approach to strengthen dialogue and contribute to transparency, confidence-building, and risk reduction efforts.