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Can antidepressants cause weight gain?

Weight gain is one of the most common concerns people have when starting an antidepressant. While some medications may contribute to weight changes, it’s often not because they directly create body fat. Increased appetite, cravings, fatigue, reduced physical activity, and appetite returning as depression improves can all play a role.

In this episode, holistic pharmacist Larry Pham explains why weight gain can happen, why you should never stop an antidepressant without medical guidance, and practical strategies that may help—including eating more protein and fiber, reducing late-night snacking, adding daily movement, and  ...