In this deep-dive episode, we unpack Early Clozapine After One Failed Antipsychotic: What PMHNPs Need to Know. Audio Overview Listen to an in-depth podcast of this post Two hosts break down the full article — no reading required. Your browser does not support audio playback. 654 patients. One failed antipsychotic. And a drug most prescribers still avoid. A March 2026 randomized clinical trial in JAMA Psychiatry just challenged one of the most deeply held assumptions in psychiatric prescribing: that clozapine belongs at the end of the line. The study found that patients with first-episode psychosis who didn’t respond to their first antipsychotic had better outcomes on clozapine than on olanzapine or amisulpride — after just one failed trial. For PMHNPs, especially those early in their careers, this matters. Clozapine has been the third rail of psych ...