In this in-depth episode of From Concept to Medicine, we take a comprehensive look at glipizide, a widely used second-generation sulfonylurea for type 2 diabetes. The episode begins with a historical overview of the sulfonylurea class and glipizide’s role in the evolution of diabetes care, comparing it to older drugs like tolbutamide and glyburide. We explore how glipizide functions—stimulating insulin release and improving tissue sensitivity—and contrast its mechanism with newer therapies like SGLT2 inhibitors, which carry lower hypoglycemia risks. Through regulatory documents, clinical trials, and expert guidance, we assess glipizide’s efficacy, dosing challenges, and safety profile, particularly its implications for kidney function and cardiovascular outcomes. The hosts also touch on its potential repurposing for neur ...