This podcast discusses the recent publication by Inoue and Weihl (2025) on myofibrillar myopathies (MFMs), focusing on their redefinition as “Z-disk-opathies.” In this episode we explore how new genetic findings challenge the traditional, histopathology-based classification and highlight key disease mechanisms, including Z-disk disruption and impaired protein homeostasis.

The episode also covers the distinction between so called, true MFMs and other myopathies with similar pathology, as well as the implications for diagnosis and future targeted therapies.