Why do two anesthetics with opposite effects on the brain's inhibitory system both produce unconsciousness , and what does the difference between them reveal about the neural architecture of conscious access? Anesthesiologist Lynn Uhrig and neuroscientist Bechir Jarraya explain how the local-global auditory paradigm, combined with propofol and ketamine in macaque monkeys, is dissecting the frontoparietal network that supports consciousness. Subscribe for more from the Convergent Science Network podcast series. Lynn Uhrig and Bechir Jarraya join Paul Verschure at the BCBT summer school to present their collaborative work using anesthesia as a tool to probe the neural substrates of consciousness. They employ the local-global paradigm, a sequence of sounds containing two levels of rule violation, originally developed by Dehaene and Naccache. Local d ...